Intensity-Modulated Radiation Therapy (IMRT) and
Image-Guided Radiotherapy (IGRT)
A breakthrough technology for
delivering image-guided radiotherapy is now
available in Houston at Houston Metro Urology
Diagnostic and Cancer Treatment Center offering new
hope to people who are battling cancer.
Intensity-modulated radiation
therapy (IMRT) is the most technologically advanced,
most precise method of external beam radiation
therapy available. IGRT takes this technology one
step further. It delivers high doses of radiation
directly to the tumor while sparing surrounding
healthy tissue.
IMAGE-GUIDED RADIOTHERAPY FOR THE TREATMENT OF
PROSTATE CANCER
Houston Metro Urology recently installed a Clinac iX™
medical linear accelerator from Varian Medical
Systems, for treating cancer with Dynamic Targeting™
image-guided radiotherapy (IGRT). This new robotic
and automated technology combines a state-of-the-art
treatment machine with sophisticated digital
imaging, tracking and monitoring tools, enabling
doctors to deliver the most accurate treatments
possible, even when treating tumors that move as the
patient breathes.
The
new system at Houston Metro Urology incorporates a
high-quality imaging device that enables clinicians
to position patients very precisely and to deliver
the radiation dose directly to a targeted area with submillimeter accuracy, guided by three-dimensional
images of the patient’s anatomy. The system’s
versatility makes it appropriate for treating a wide
range of abnormalities, from small metastases to
larger tumors, even in cases where the tumor is
close to critical structures like the spinal cord or
the optic nerve. A “respiratory gating” tool
compensates for normal respiratory motion during
treatment. Taken together, these tools deliver
extremely precise treatments with the potential for
better outcomes and fewer side effects.
The Clinac iX, with its On-Board Imager™ device, is
visually compelling. Housed in a treatment vault
visible through glass windows or via closed-circuit
television, the machine stands approximately nine
feet tall and rotates 360 degrees around the patient
to deliver radiation beams from almost any angle.
The On-Board imager is attached to the machine on a
pair of robotic arms that extend out on either side
of the patient to generate anatomical images that
will guide the treatment. Sophisticated
image-matching software shows patient anatomy on
computer monitors in a futuristic control console
outside the treatment room.
SmartBeam IMRT involves varying
(or modulating) the intensity of the radiation
(in this case, X-rays), being used as therapy for
cancer. It is a new form of radiation therapy that
uses computer-generated images to plan and then
deliver more tightly focused radiation beams to
cancerous tumors than is possible with conventional
radiotherapy. With this capability, clinicians can
deliver a precise radiation dose that conforms to
the shape of the tumor, while significantly reducing
the amount of radiation to surrounding healthy
tissues. Consequently, the technique can increase
the rate of tumor control while significantly
reducing adverse side effects.
The
Treatment Process
Consultation The IMRT treatment process generally
consists of several steps, including consultation,
positioning, imaging, treatment planning, plan
verification, and treatment delivery. A dedicated
team of medical professionals will guide you and
work with you every step of the way.
The first step is to meet with
your radiation oncologist, who will review your
medical history pathology reports, conduct a
physical examination and set an appointment for you
to begin the positioning and imaging process.
Treatment Preparation Most cases require a treatment preparation
session. Special molded devices that help the
patient maintain the same position every day are
developed at this point. Colored, semi-permanent
ink may be used to mark the patient’s skin, to
assist in positioning the patient for treatment by
aligning the radiation equipment with the targeted
area. A special CT scan in the treatment position
is sometimes taken, for use as a reference image
later on in the process. The treatment preparation
session might take from thirty minutes to an hour
and the CT scan might take an additional 15-30
minutes.
Following the CT scan, the
radiotherapy treatment planning process usually
takes several days. When the plan is complete, the
patient is given an appointment to begin radiation
treatments.
Treatment Planning Using the information gathered in
positioning and imaging, the radiation oncologist,
radiation physicist, and dosimetrist (a person
specially trained to calculate and plan radiation
doses) work together to design the best IMRT
treatment plan for your situation. As part of the
treatment planning, your medical team conducts
extensive quality assurance testing with the
treatment equipment to be sure that your planned
treatment can be accurately and easily carried out.
The first IGRT treatment
session is sometimes longer than subsequent ones so
that additional X-ray films and checks can be done.
A typical IMRT treatment session lasts about 15
minutes.
In the treatment room, the
radiation therapist uses the marks on the patient’s
skin to locate the treatment area. The patient is
positioned on a treatment table. Sometimes, special
molded devices are used to help with rough
positioning.
The radiation therapist leaves
the treatment room and remotely controls a digital
On-Board Imager™ device to fine-tune the patient’s
position and move the treatment couch into final
position. The On-Board Imager rotates around the
patient to take digital images of the targeted
area. Usually two or more images are taken from
different angles. A complete rotation of the
machine may be used to generate a three-dimensional
image. These images are then used to guide the
final adjustments of the treatment couch.
Although the patient is alone
in the treatment room, he or she can be seen on a
television screen or through a window in the control
room. The therapist can talk with the patient
through an intercom. Patients do not see or hear
the radiation and usually do not feel anything.
Treatment Delivery
Radiation therapy usually is
given five days a week for six or seven weeks. When
radiation is used for palliative care, the course of
treatment lasts for two to three weeks. For each
radiation therapy session, the patient is in the
treatment room for about 15 to 30 minutes. These
types of schedules, which use small amounts of daily
radiation rather than a few large doses, help
protect normal body tissues in the treatment area.
Weekend rest breaks allow normal cells to recover.
The total dose of radiation and the number of
treatments a patient needs depend on the size and
location of the cancer, the type of tumor, the
patient’s general health and other factors.
The daily treatment
sessions usually last about fifteen to thirty
minutes. Most of this time is used by the radiation
therapist to ensure accurate positioning of your
treatment area. You may notice laser lights in the
room; these help the therapist make sure that you
are level and straight on the treatment table.
Dose delivery itself
may take only a few minutes. The treatment
radiation given by the linear accelerator is
invisible and you will not feel it, just as you do
not feel an X-ray. The accelerator emits a buzz as
it produces the radiation beams. You may also hear
the quiet, high-pitched sound of the MLC and see the
leaves move. It is important to lie as still as
possible during this time, so that the radiation
dose is delivered to the exact same treatment area
each time.
The accelerator will
move around you to the first treatment angle
specified in your treatment plan, administer
radiation, then move to the next specified angle to
administer radiation. The number of angles depends
upon your treatment.
Follow-Up Care
When your course of treatment
is completed, you will have a series of follow-up
visits in which your doctor will monitor your
condition and the effects of the treatment. Your
doctor may request blood tests, X-rays, and/or scans
at these appointments. Discuss with your doctor how
to stay healthy after treatment. Ask about
nutrition, exercise, and environmental changes that
could help you maintain a healthy lifestyle.
Equally as important, find out about support groups
for cancer patients and survivors, so that you can
connect with others who have had similar
experiences.
Patient Q & A
What are the effects of
treatment?
External radiation therapy does not cause a
patient’s body to become radioactive. Patients need
not avoid being with other people because of
treatment. Even hugging, kissing, or having sexual
relations with others pose no risk to them of
radiation exposure.
Side effects of radiation
therapy most often are related to the area that is
being treated. Most side effects that occur during
radiation therapy, although unpleasant, are not
serious and can be controlled with medication or
diet. They usually go away within a few weeks after
treatment ends. With Dynamic Targeting™ IGRT, side
effects are minimized, and some patients have no
side effects at all.
How will IMRT affect my
daily routine?
Many patients are able to continue most of their
usual activities during treatment. Listen to your
body and allow yourself the extra rest you may
need. If your energy level decreases, it should
return to normal within four to six weeks after
treatment ends.
How will my eating be
affected?
If your treatment area is near your digestive
tract, you may lose interest in food during
treatment. It is very important, however, not to
loose weight during treatment. Try to eat small
meals often, eat a variety of foods, and keep your
protein and calorie intake high.
Will I lose my hair?
IMRT, like other forms of radiation therapy can
cause temporary hair loss, but only in the area
being treated. The amount of hair that grows back
depends on the amount of radiation you receive.
Is IGRT Expensive?
Treatment of cancer with radiation can be costly. It
requires very complex equipment and the services of
many health care professionals. The exact cost of
your radiation therapy will depend on the type and
number of treatments you need.
Medicare does provide
additional reimbursement for the various steps
involved in delivering IGRT, whether the treatment
occurs in a hospital outpatient environment or in a
freestanding outpatient clinic. Many health
insurance policies cover charges for radiation
therapy. It's a good idea to talk with your insurer
or with your doctor's office staff or the hospital
business office about your policy and how expected
costs will be paid.
-------------------------------------------------------------------------------------------- To get answers to more of
your questions regarding IGRT, contact your treating
urologist
at 713-351-0644, or the radiation therapist
(Dr. John Van) at the HMU
Center on Richmond. Click here
to download a brochure about IMRT.