MUSE (alprostadil urethral suppository) FAQ

What is MUSE?
MUSE represents a unique approach for the treatment of erectile dysfunction (commonly called impotence). It is based on the discovery that the urethra (the tube in the penis for urine to pass from the bladder to the outside of the body) can absorb certain medications into the surrounding erectile tissues, thereby creating an erection. There are four dose strengths of the medication alprostadil that are currently available. The MUSE applicator contained in each foil pouch is intended for a single administration only.
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How long will the effect of MUSE last?
An erection should begin within five to10 minutes after administering MUSE. The duration of effect is approximately 30-60 minutes, but the actual duration will vary from patient to patient.
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What is MUSE used for?
MUSE is indicated for the treatment of impotence. Impotence is defined as the inability to achieve and maintain an erection sufficient for sexual intercourse.
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Who should not use MUSE?
You should not use MUSE if you have the following:

Hypersensitivity to alprostadil

Altered anatomy of penis from birth defect, injury or prior surgery

Have been advised not to engage in sexual activity

Conditions that might result in long-lasting erections, such as sickle cell anemia or trait, leukemia, or multiple myeloma

A pregnant partner, unless the man uses a condom to prevent the medication from being absorbed in the vagina

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What are the possible side effects of MUSE?
The most common side effects that have been reported using MUSE are:

Aching in the penis, testicles, legs and in the area between the scrotum and the rectum
Warmth or burning sensation in the urethra
Redness of the penis due to increased blood flow
Minor urethral bleeding or spotting due to improper administration

Side effects less frequently reported:

Prolonged erection.(more than four hours)
Swelling of leg veins
Light-headed sensation
Fainting
Rapid pulse

Most of the side effects reported in men are relatively minor, such as burning and aching in the penis and groin. Rarely noted are prolonged erections, light-headedness, dizziness, fainting, rapid pulse, and swelling of the leg veins. If you feel dizzy, light-headed, faint or experience rapid pulse, lie down immediately and raise your legs. If symptoms persist, promptly call us. Because of the potential for these side effects, MUSE dosage adjustment should be carried out by us.
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How often can I use MUSE?
Do not use MUSE more than twice in a 24-hour period.
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What are the possible side effects of MUSE for your partner?
The most common reported side effects observed in women whose partners use MUSE are mild vaginal itching or burning. Using a water-based lubricant, such as K-Y Jelly, can help make vaginal penetration easier. Your partner may want to consult her physician if she has not had sexual intercourse for an extended period of time.
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Will MUSE prevent pregnancies or STDs?
MUSE has no contraceptive properties. If your partner is pregnant or even of childbearing age, it should not be used for sexual intercourse unless the man uses a condom barrier. It will also not protect you or your partner from sexually transmitted diseases, such as Chlamydia, gonorrhea, herpes or AIDS.
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How should I store MUSE?
MUSE should be stored in a refrigerator. It may be kept at room temperature for up to 14 days prior to use. When traveling, store MUSE in a portable ice pack or cooler. Do not place in baggage storage areas where MUSE may be exposed to extremes in temperature.
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Will insertion of MUSE hurt?
At first, you may feel some minor discomfort from insertion. Urinating prior to administration will reduce the chance of discomfort or abrasions and is important for dissolving the medicated pellet. Be sure to straighten your penis to its full length when inserting the MUSE applicator. With repeated use, administration will become much easier.
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After I administer MUSE, can we immediately lie down and begin sexual intercourse?
You can begin sexual activity, but having the man lie down, especially on his back, shortly after administration is not recommended. This will reduce blood flow to the penis and may reduce the erection. It is important to sit, stand or walk about for 10 minutes after administration. Many couples have used this time to incorporate various types of foreplay. After this initial period, you can assume different positions leading to sexual intercourse. Some couples have noticed that the erection is better maintained in positions that favor blood flow into the penis during intercourse.
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What will the erection be like? How will it compare to the erections I had when I was younger?
An effective dose of MUSE should produce an erection sufficient for sexual intercourse. MUSE may not create an erection such as those you experienced when you were younger. Some men may experience mild pain and aching in the penis or groin area. Also, your erection may continue after you have an orgasm or ejaculate.
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How do I know if I have the correct dose of MUSE?
You and your physician will determine the appropriate dose of MUSE. If your erection cannot be maintained for the time needed to have foreplay and sexual intercourse, you may need to have your dose increased. Similarly, an erection that lasts longer than desired may require a dose decrease. Call us if you suspect you may require a dosing adjustment.
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After my erection is over, will my penis feel sensitive?
You penis may feel full, warm, and somewhat sensitive to the touch. These effects are normal and may last a few hours.
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Can I reuse MUSE?
No. Each MUSE is intended for single-dose application only.
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How do I dispose of the MUSE applicator?
After you have administered MUSE, replace the cap on the applicator, place in the opened foil pouch, fold and discard as normal household waste.
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If my erection lasts longer than desired, what should I do?
Call us promptly if you have a rigid erection that lasts more than four hours. Applying ice packs to the inner thigh may shorten the duration of the erection, since the cold will restrict blood flow to the penis. If used, ice packs should be applied alternately to each inner thigh for a period not exceeding 10 minutes.
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CHILDHOOD UROLOGICAL PROBLEMS : GLOSSARY : MEN'S KIDNEY PROBLEMS : WOMEN'S KIDNEY PROBLEMS : PROSTATE PROBLEMS : SEXUAL AND MALE GENITALIA PROBLEMS : MEN'S URINARY INCONTINENCE AND BLADDER PROBLEMS : WOMEN'S URINARY INCONTINENCE AND BLADDER PROBLEMS